光応答性核酸を用いた遺伝子操作法の開発

概要

論文の詳細を見る
While many methods for enzymatic and chemical ligation of DNA fragment via a native phosphodiester bond or non-native linkages have been demonstrated, there are only a few methods for photoinduced nonenzymatic chemical ligation. The merit of the photochemical ligation avoiding the need for additional reagent is obvious. Furthermore, their actions are controllable within space and time by the choice of proper irradiation methods. The photoligation methods can be used as a tool for DNA engineering and nanotechnology, and as photoregulated diagnostic and therapeutic agents. Therefore, the target in my research program is the development about phototriggered DNA manipulation via intelligent nucleic acids toward for the next generation DNA manipulation.
日本生物物理学会の論文
2006-05-25