Cyclic Nucleotide Response Element Binding Protein (CREB) Activation Promotes Survival Signal in Human K562 Erythroleukemia Cells Exposed to Ionising Radiation/Etoposide Combined Treatment
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概要
- 論文の詳細を見る
Anticancer therapy addresses the destruction of tumour cells which try to counteract the effect of drugs and/or ionising radiation. Thus the knowledge of the threshold over which the cells do not resist such agents could help in the setting up of therapy protocols. Since a key role was assigned to Cyclic nucleotide Response Element Binding protein (CREB) multigenic family (which is composed of several nuclear transcription factors involved in c-AMP signalling in cell differentiation, proliferation, apoptosis, survival and adaptive response and in hematopoiesis and acute leukemias), attention was paid to the activation of Erk cascade and of the downstream kinases and transcription factors such as p90RSK and CREB. K562 erythroleukemia cell survival to 1.5 Gy ionising radiation with or without etoposide treatment seemed to involve Erk phosphorylation which, regulating p90 RSK, should activate CREB. In parallel, p38 MAP kinase activity down-modulation, along with low caspase-3 activity, and no modification of Bax and Bc12 levels, supported such evidence. Thus, endogenous CREB activation, triggering a potent survival signal in K562 cells exposed to 1.5 Gy with or without etoposide, led us to suggest that using specific inhibitors against CREB, such as modified phosphorothionate oligodeoxynucleotides (ODN) correspending to CREB-1 sequence, anticancer therapy efficacy could be improved.
- 日本放射線影響学会の論文
- 2006-06-30
著者
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Rana Rosa
Dipartimento Di Biomorfologia Universita G.d'annunzio
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Rana Rosa
Istituto Di Morfologia Umana Normale Universita G. D'annunzio
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Cataldi A
Univ. G. D'annunzio Chieti Ita
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Cataldi Amelia
Dipartimento Di Biomorfologia Universita G.d'annunzio:cattedra Di Anatomia Umana Facolta Di Far
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Cataldi Amelia
Dipartimento Di Biomorfologia
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GIACOMO Viviana
Dipartimento di Biomorfologia, Universita G.D'Annunzio
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RAPING Monica
Istituto per i Trapianti d'Organo e l'Immunocitologia del CNR
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GENOVESI Domenico
Unita Operativa di Radioterapia Oncologica, Ospedale Clinicizzato
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Raping Monica
Istituto Per I Trapianti D'organo E L'immunocitologia Del Cnr
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Giacomo Viviana
Dipartimento Di Biomorfologia Universita G.d'annunzio:cattedra Di Anatomia Umana Facolta Di Far
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Di Giacomo
Dipartimento Di Biomorfologia Universita G. D' Annunzio
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Genovesi Domenico
Unita Operativa Di Radioterapia Oncologica Ospedale Clinicizzato
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Rapino Monica
Istituto per i Trapianti d'Organo e l'Immunocitologia del CNR
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Rapino Monica
Istituto per i Trapianti d'Organo e l'Immunocitologia del CNR
関連論文
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- Cyclic Nucleotide Response Element Binding Protein (CREB) Activation Promotes Survival Signal in Human K562 Erythroleukemia Cells Exposed to Ionising Radiation/Etoposide Combined Treatment
- Phosphoinositide Signalling Enzymes in Human T Lymphocytes: Modulation of Phosphoinositidase C Isoform Gamma 1 upon Interferon Treatment
- Relationship Between Nuclear Ribonucleoprotein Arrangement and Cell Proliferation in Burkitt Lymphoma Cells
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