アフェレシス用膜型分離器の牛血系評価法(<特集>アフェレシス療法における技術的進歩 : 最近のトピックスから)

概要

論文の詳細を見る
Several types of performance data for membrane plasma separators and plasma fractionators has been reported by manufacturer's catalogues and scientific presentations by clinical researchers during academic meetings. However, we cannot compare these data under same conditions because they were obtained by different methods and under different conditions such as flow rates. From this viewpoint, performance evaluation using bovine blood was introduced in this study to evaluate the performance of membrane plasma separators and plasma fractionators under the same conditions, which were similar to clinical situations. For an example, a part of 5,000ml of bovine blood in a tank was circulated at 100ml/min and fed to the plasma separator. Both filtrated plasma at 25ml/min of filtration flow rate and the retentate of the blood at 75ml/min were returned to the original tank in a closed circuit. Samples at inlet, outlet and filtrated portions in the plasma separator were collected and tested for albumin, LDL, IgG, HDL, total cholesterol and total protein. Values for the sieving coefficient of the plasma separator were calculated from these data. A good correlation between clinical data and the experimental data was obtained within 1 hour because there was no serious membrane fouling. Bovine blood testing was effective for performance evaluation of membrane plasma separators and plasma fractionators.
日本アフェレシス学会の論文
2006-05-31