Streptococcus mutansの器壁付着性に関与する菌体外多糖について : I.器壁への付着能を異にした画分の不溶性グルカンの構造について : II.不溶性グルカンの分画と器壁付着能について : III.多糖分解酵素共存下における多糖合成と付着性について
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In vitro studies were performed on the extracellular polysaccharides responsible for the adherence of Strep. mutans to glass surface. Following results were obtained: 1. In proportion of α-1:3- and α-1:6-glucosidic linkages, there were no remarkable differences between the adhered and not adhered insoluble glucan produced by Strep. mutans strain FIL from sucrose at early stage of cell growth. The adherence ability of insoluble glucan produced at early stage of cell growth does not mainly depend on the proportion of α-1:3- and α-1:6-glucosidic linkages but may depend on other structural changes such as conformation or molecular weight derived from the differences of fields of glucan synthesis. 2. Apparent correlation between the adherence ability of streptococci to glass surface and the insoluble glucan-1 producing ability was observed in the adherence assay system by seven cultured streptococci having different insoluble glucan producing ability. Similar correlation between the amount of adhered insoluble glucan and insoluble glucan-1 producing ability was confirmed in the cell-free adherence assay system by crude enzyme preparation from Strep, mutans strain 6715 under various conditions. 3. The amounts of adhered insoluble glucan and insoluble glucan-1 were reduced by addition of α-1:6- or α-1:3-glucanase in cell-free adherence assay system. However, the correlation between the amount of adhered insoluble glucan and insoluble glucan-1 producing ability was also observed in the presence of each glucanase. The insoluble glucan-1 synthesized in the presence of α-1:6-glucanase and the insoluble glucan-1 synthesized in the presence of α-1:3-glucanase seemed to have difference in the adhesive property. Each insoluble glucan-1 was fractionated in same fraction according to the solubility, but the difference in adhesive property of each insoluble glucan-1 synthesized in the presence of α-1:6- or α-1:3-glucanase may be explained by differences of other physicochemical properties or chemical structures.
- 特定非営利活動法人日本歯周病学会の論文
- 1978-03-28
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- Streptococcus mutansの器壁付着性に関与する菌体外多糖について : I.器壁への付着能を異にした画分の不溶性グルカンの構造について : II.不溶性グルカンの分画と器壁付着能について : III.多糖分解酵素共存下における多糖合成と付着性について