7 ヒト・レトロウイルスによる宿主細胞癌化機構(シンポジウムゲノム情報と感染症(診断・治療・予防への応用),第580回新潟医学会)

概要

論文の詳細を見る
Human T-cell leukemia virus type 1 (HTLV-1) is an etiologic agent of adult T-cell leukemia (ATL). Around 5% HTLV-1-infected individuals develop ATL averagely 50-60 years after the infection. Thus, in addition to HTLV-1, multiple host factors are involved in the development of ATL. Unlike to HTLV-1, an allied virus HTLV-2 is not associated with ATL or similar leukemia. HTLV-1 and HTLV-2 immortalizes human T-cells in vitro, and their efficiencies are equivalent. These results suggest that HTLV-1 has additional activities to host T-cells resulting in ATL development. We will discuss the roles of HTLV-1 tax1 and HTLV-2 tax2 genes in the distinct pathogenic activities between two viruses.
新潟大学の論文
2004-11-10