2 Helicobacter pyloriの病原性因子と胃十二指腸疾患(シンポジウムゲノム情報と感染症(診断・治療・予防への応用),第580回新潟医学会)

概要

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Approximately 20% of Helicobacter pylori (H. pylori)-infected individuals develop clinically significant diseases such as peptic ulcer, gastric adenocarcinoma or gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It is unknown which bacterial, host, and environmental fac-tors are the critical determinants that predispose to these clinical manifestations of H. pylori infection. Host factors that influence acid secretion are potentially good candidates as factors that influ-ence the outcome of an H. pylori infection. The proinflammatory cytokine, interleukin (IL)-1β, is a candidate in this regard in that it is expressed in the gastric mucosa infected with H. pylori. Here we show that IL-1 genetic polymorphisms influenced H. pylori- related gastric mucosal IL-1β Levels and were related to gastric inflammation and atrophy, factors thought to be important in gastric carcinogenesis. Experience with other bacterial pathogens suggests that H. pylori strain specific factors also influence the pathogenicity of H. pylori as well as the risk of developing different H. pylori-related diseases. We show that the number of repeats in the 3' region of the cagA gene was closely related to gastric atrophy and gastric cancer, and the oipA functional status was closely related to clinical presentation, H. pylori density and gastric inflammation.
2004-11-10