DMBA誘導ハムスター舌癌モデルにおけるビタミンの影響
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Antitumor effect of vitamin E and polyprenoic acid (E-5166) were examined in lingual carcinoma of golden syrian hamsters induced by 1.0% DMBA aceton solution. In normal hamsters, immune response was investigated by lymphoproliferative assays with phytohemagglutinin and concanavalin A were most enhanced significantly when doses of 20 mg/kg/day for vitamin E was injected into the intraperitoneal cavity for 14 days. Therefore, with carcinogenic procedure, vitamin E was injected intraperitoneally for 3 times a week for 11 weeks at the doses of 20 mg/kg/day. With carcinogenic procedure, E-5166 was administrated by gavage for 3 times a week for 15 weeks at the doses of 10mg/kg/day and 40mg/kg/day. The results were as follows : 1) Doses of 20 mg/kg/day of vitamin E showed the tendency to inp.ibit tumor growth and carcinogenesis. 2) E-5166 groups showed inhibition of tumor growth. 3) Doses of 40 mg/kg/day of E-5166 showed significant inhibition of carcinogenesis. 4) Vitamin E and E-5166 groups were enhanced cellular immunity assessed by the lymphoproliferative assay than in control at the 15 weeks. 5) Number of white blood cell and lymphocyte showed the tendency to inhibit a decrease in vitamin E and E-5166 groups as compared with control at the 15 weeks. The combined effect of vitamin E or E-5166 and FT207(FT) was examined in lingual carcinoma of hamster. FT was injected intraperitoneally for 6 times a week from the 12th through the 15th week at the doses of 100mg/kg/day. The results were as follows : 1) The combined administration of vitamin E or E-5166 and FT were suppressed the tumor growth than FT alone. 2) Vitamin E and E-5166 were effective against the immunosuppression induced by FT at the 15 weeks. These results suggested that inhibition of tumor growth and carcinogenesis were caused by immunomodulate effect of vitamin E and E-5166.
- 神戸大学の論文
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