Expression of Intermediate Filament Proteins in Human Lung Cancer Tissues, Cultured Lung Cancer Cell Lines and their Transplanted Tumors : An Immunohistochemical Study

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Human lung cancer tissues, cultured lung cancer cell lines and their transplanted tumors were examined for their expression of various types of intermediate filament proteins using immunoperoxidase and immnofluorescence techniques. The lung cancers used were classified into four major histological types according to the World Health Organization classification. All types of lung cancers expressed either 56-64kD or 44-54kD or both keratin proteins. Thus, large cell carcinomas and small cell carcinomas also possessed an epithelial nature as well as that of squamous cell carcinoma and/or adenocarcinoma. In addition, the degree of cell differentiation could be demonstrated according to staining with the antibodies to 56-65kD keratin and 44-54kD cytokeratin. On the other hand, it was noteworthy that the two cell lines derived from a poorly differentiated adenocarcinoma and from a large cell carcinoma respectively expressed neurofilament. From our resuts and those of other authors, the neurofilament protein may exist not only in small cell carcinomas but also in non-small cell carcinomas, although very low in frequency. The expression of neurofilament in small cell carcinoma is probably incidental rather than constant so that it might not become a specific diagnostic tool. We also conclude that the expression of vimentin is incidental in lung cancers (one out of 15 large cell carcinomas in our data). No lung cancer contained desmin or glial fibrillary acidic protein. Neuron specific enolase (NSE), an immunocytochemical marker for the diffuse neuroendocrine system, is no doubt a useful and consistent one for scc.
北里大学の論文
1987-12-31

Expression of Intermediate Filament Proteins in Human Lung Cancer Tissues, Cultured Lung Cancer Cell Lines and their Transplanted Tumors : An Immunohistochemical Study

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