Potentiation of Neuromuscular Blockade by Calcium Channel Blockers
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概要
- 論文の詳細を見る
A significant reduction was noticed in the amount of vecuronium needed to maintain steady neuromuscular blockade at 20% twitch height (T1) in patients given nicardipine intraoperatively. Bolus injection of either nicardipine or diltiazem during constant infusion of vecuronium produced transient depression of T1 and the train-of-four ratio (TOFR). Reversal of neuromuscular blockade with a choline esterase inhibitor (neo-stigmine) was not retarded by previous administration of Ca-channel blockers but concurrent administration of anticholine-esterase agent and Ca-channel blockers caused a delay in recovery from motor blockade. Monitoring of neuromuscular junction activity is strongly recommended whenever a large cumulative dose of Ca-channel blockers is used.
- 東海大学の論文
著者
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Takaya Tetsuo
Department Of Anesthesiology Tokai University School Of Medicien
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Takiguchi Mamoru
Department Of Anesthesiology Tokai University School Of Medicine
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