A Study on the Origins of Urinary Serotonin and Tryptamine

概要

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A senstitive gas chromatography/negative ion chemical ionization mass spectrometric (GC/NICIMS) method was devised and by using deuterated L-tryptophan-3,3-d_2(Trp-d_2) as a tracer, the detailed in vivo metabolism of serotonin (5-HT) and tryptamine (TA) was investigated. A human was administered orally with 10 mg/kg Trp-d_2 and rats were injected intra-peritoneally with 50 mg/kg Trp-d_2. The ratios of the level of 5-HT-d_2 derived from Trp-d_2 to that of endogenous 5-HT-d_0 and that of TA-d_2 to that of TA-d_0 were measured in urine arid some organs of rats at times up to 4 hr after administration. It is concluded that urinary excretion of 5-HT might reflect its turnover in the central nervous system and that of TA might reflect its peripheral turnover.
東海大学の論文