The vir Locus and Phase-Variation in Bordetella pertussis(II. Molecular Biological and Genetic Analysis of Bordetella pertussis)(Current Studies on Future Vaccines)

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概要

• 論文の詳細を見る

• By a phenomenon known as phase-variation Bordetella pertussis is capable of changing between a virulent-phase in which multiple virulence-associated determinants are expressed, and an avirulentphase in which the virulence-associated determinants are not expressed. Mutations in the vir locus of B. pertussis have a similar effect. We have examined the state of the vir locus in each of a series of strains derived one from the other by phase-variation. We have found that a single base-pair change is associated with the change between the virulent and avirulent phases. This single base-pair change corresponds to a frameshift mutation in the vir locus.

• 東海大学の論文
• 1988-09-22

著者

• Falkow Stanley

  Department Of Medical Microbiology Stanford University

• STIBITZ Scott

  Center for Biologics Evaluation and Research, Food and Drug Administration

• AARONSON Wendy

  Center for Biologics Evaluation and Research, Food and Drug Administration

• MONACK Denise

  Department of Medical Microbiology, Stanford University

• Stibitz Scott

  Center For Biologics Evaluation And Research Food And Drug Administration

• Monack Denise

  Department Of Medical Microbiology Stanford University

• Aaronson Wendy

  Center For Biologics Evaluation And Research Food And Drug Administration

関連論文

• Staphylococcus aureus infection of human primary keratinocytes
• The vir Locus and Phase-Variation in Bordetella pertussis(II. Molecular Biological and Genetic Analysis of Bordetella pertussis)(Current Studies on Future Vaccines)

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