An Onogoing Surveillance Study of Persistent Crying and Hypotonic-hyporesponsive Episodes Following Routine DTP Immunization : A Preliminary Report(B. Vaccine Schedules: Their Pelationship to Current Epidemiology)(II. The Eradication of Pertussis: Current

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Hypotonic-hyporesponsive episodes and persistent crying are specific complications of pertussis immunization. Hyperinsulinemia, hypoglycemia, and leukocytosis have been noted after pertussis vaccine administration in a murine model. Five children with hypotonic-hyporesponsive episodes and 6 children with persistent crying following DTP immunization were studied. The children were found to have leukocytosis acutely, similar to findings reported in children following routine DTP immunization. No abnormalities were noted in plasma insulin or serum glucose. Five of 6 chilren with persistent crying had severe local reactions, suggesting that localized inflammation may be a cause of persistent crying.
東海大学の論文
1988-09-22