Age at Pertussis Immunization as it Relates to Current Epidemiology and Disease Control(B. Vaccine Schedules: Their Pelationship to Current Epidemiology)(II. The Eradication of Pertussis: Current Unsolved Epidemiologic, Clinical and Public Health Problems

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概要

• 論文の詳細を見る

• Decisions about vaccine use involve the risks of disease, efficacy of the vaccine, and adverse events associated with the vaccine. The goal is to provide protection at the earliest possible age. Available data suggest that even very young infants develop a protective response to a multi-dose series of pertussis vaccine. There are not conclusive data to indicate that true reactions to pertussis vaccine are age-related. The approach in the United States has been to recommend pertussis vaccination early in infancy, usually giving pertussis vaccine in combination with tetanus and diphtheria toxoids as DTP at 2, 4 and 6 months of age with a fourth dose at 15-18 months and a booster dose at 4-6 years just prior to school entry. In recent years, concern about adverse effects possibly caused by pertussis vaccine have led to suggestions that the administration of DTP be delayed by varying periods. To estimate the effects of a 6-month delay in the primary vaccination series, we conducted a decision analysis, following two hypothetical cohorts of 3.7 million children each from birth to their fourth birthday. One cohort was vaccinated at 2, 4, 6 and 18 months of age (the current schedule) whereas the other cohort was vaccinated at 8, 10, 12 and 18 months of age (the proposed schedule). Under base case conditions, assuming no change in adverse events attributable to DTP, a 6-month delay in initiating DTP vaccination would result in 636 more reported cases of pertussis, many with complications. Variable changes would be expected in adverse events associated with DTP by chance-fewer instances of SIDS and infantile spasms, slightly more instances of encephalopathy, and a substantial increase in seizures. This analysis supports continuation of the current schedule of immunizing young infants in the United States.

• 東海大学の論文
• 1988-09-22

著者

• WASSILAK Steven

  Division of Immunization, Center for Prevention Services, Centers for Disease Control

• Hinman Alan

  Center For Prevention Services Centers For Disease Control

• Mortimer Edward

  School Of Medicine Case- Western Reserve University

• FUNKHOUSER Ann

  School of Medicine, Case- Western Reserve University

• ORENSTEIN Walter

  Division of Immunization, Center for Prevention Services Centers for Disease Control

• Wassilak Steven

  Division Of Immunization Center For Prevention Services Centers For Disease Control

• Funkhouser Ann

  School Of Medicine Case- Western Reserve University

• Orenstein Walter

  Division Of Immunization Center For Prevention Services Centers For Disease Control

関連論文

• Current Epidemiology of Pertussis in the United States(A. Current Epidemiology of Pertussis)(II. The Eradication of Pertussis: Current Unsolved Epidemiologic, Clinical and Public Health Problems which Impede This Goal)(Clinical Aspects of Acellular Pertus
• Age at Pertussis Immunization as it Relates to Current Epidemiology and Disease Control(B. Vaccine Schedules: Their Pelationship to Current Epidemiology)(II. The Eradication of Pertussis: Current Unsolved Epidemiologic, Clinical and Public Health Problems

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