Antral Mucosal Bile Acids in Two Types of Chronic Atrophic Gastritis

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概要

• 論文の詳細を見る

• Bile acids may damage the gastric mucosa, and they are cocarcinogenic in experimental colonic and gastric cancer. Chronic atrophic gastritis (CAG) and chronic atrophic gastritis with intestinal metaplasia (CAGIM) are associated with gastric carcinoma. We, therefore, analysed bile acids in the antral mucosa in controls (n=10), in patients with CAG (n=12) and CAGIM (n=20). In both forms of chronic antral gastritis, total mucosal bile acid concentrations drop, caused mainly by lower primary bile acids. The proportions of secondary bile acids rise, in particular of toxic lithocholic acid. This is probably caused by bacterial activity in the stomach. Whether secondary bile acids, especially lithocholic acid, alone or in combination with other bacterial degradation products, influence gastric carcinogenesis remains to be elucidated in further studies.

• 東海大学の論文

著者

• Kurtz W

  The Center Of Internal Medicine Department Of Gastroenterology:dept. Of Gastroenterology Zim Univers

• Kurtz Winfried

  The Center Of Internal Medicine Department Of Gastroenterology:dept. Of Gastroenterology Zim Univers

• Leuschner Ulrich

  The Center Of Internal Medicine Department Of Gastroenterology

• DIKIMLI Aydin

  The Center of Internal Medicine, Department of Gastroenterology

• CLASSEN Meinhard

  The II. Medical Clinic of the Technical University of Munich West Germany

• Dikimli Aydin

  The Center Of Internal Medicine Department Of Gastroenterology

• Classen M

  Technical Univ. Munich Munich Deu

関連論文

• Antral Mucosal Bile Acids in Two Types of Chronic Atrophic Gastritis

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