Experimental Murine Leishmaniasis and the Th1/Th2 Cell Concept
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概要
- 論文の詳細を見る
Herein, the current knowledge about the immune response during murine cutaneous leishmaniasis is summarized. Special regard is given to the characteristics and generation of Th1 and Th2 cells during this disease. Originally established on the basis of different cytokines produced by T cell clones, it is now known that the Th1/Th2 concept really defines totally different immune pathways that affect most, if not all cells of the immune system. Murine experimental leishmaniasis was the first model to confirm the relevance of the Th1/Th2 concept in vivo. In particular, data from this laboratory will be presented on the role of different IL-4 receptor allotypes, on the role of the transcription factor interferon-regulatoryfactor-1 (IRF-1) and the importance of the enzyme inducible NO synthase (iNOS). This work was supported by the SFB 263 and the Fonds der Chemischen Industrie.
- 東海大学の論文
- 1998-08-29
著者
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Roellinghoff M
Inst. Klinische Mikrobiologie Immunologie Und Hygiene Erlangen Deu
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Gessner A
Institut Fur Klinische Mikrobiologie & Immunologie University Of Erlangen
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GESSNER Andre
Institute of Clinical Microbiology, University of Erlangen/Nurnberg
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ROLLINGHOFF Martin
Institute of Clinical Microbiology, University of Erlangen/Nurnberg
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LOHOFF Michael
Institute of Clinical Microbiology, University of Erlangen/Nurnberg
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Lohoff M
Inst. Klinische Mikrobiologie Immunologie Und Hygiene Erlangen Deu
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Lohoff Michael
Institut Fur Kinische Mikrobiologie Immunolgie Und Hygiene
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Gessner Andre
Institute Of Clinical Microbiology And Immunology University Of Erlangen-nurnberg
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BOGDAN Christian
Institut fur Klinische Mikrobiologie & Immunologie, University of Erlangen
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Lohoff Michael
Institute Of Clinical Microbiology And Lmmunology University Of Erlangen-nurnberg
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Rollinghoff Martin
Institue Of Clinical Microbiology University Of Erlangen-nurnberg
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Bogdan Christian
Institut Fur Klinische Mikrobiologie & Immunologie University Of Erlangen
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GESSNER Andre
Institut fur Klinische Mikrobiologie & Immunologie, University of Erlangen
関連論文
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- IL-27 inhibits the development of regulatory T cells via STAT3
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- Analysis of cytokine patterns produced by individual CD4^+ lymph node cells during epxerimental murine leishmaniasis in resistant and susceptible mice
- Experimental Murine Leishmaniasis and the Th1/Th2 Cell Concept
- Effect of IL-7 treatment on Leishmania major-infected BALB.Xid mice:enhanced lymphopoiesis with sustained lack of B1 cells and clinical aggravation of disease
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- Co-transfer of B cells converts resistance into susceptibility in T cell-reconstituted, Leishmania major-resistant C.B-17 scid mice by a non-cognate mechanism