Chelerythrine Inhibits the Secretory Response of Human Blood Platelets without Specifically Inhibiting Protein Kinase C.

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概要

• 論文の詳細を見る

• Chelerythrine (chloride) has previously been documented to be a potent and selective inhibitor of the serine/threonine-specific protein kinase C (PKC). In this study, it was shown that 10μM chelerythrine completely inhibited serotonin secretion and partially inhibited phosphatidic acid formation in human blood platelets activated by thrombin (1U/ml). However, there was no effect on PKC activity as assessed by the level of phosphorylation of the 47K protein. Therefore, chelerythrine has been shown not to be a specific inhibitor of PKC. Without specifically affecting PKC activity, it is nevertheless capable of completely inhibiting platelet secretion, indicating that it may affect the signal transduction pathway responsible for platelet secretion at a point downstream or independent of PKC.

• 東海大学の論文

著者

• Novales-li Philipp

  Department Of Pharmacology University Of Oxford Mansfield Road Oxford Oxi 3qt United Kingdom:departm

• LANE Trevor

  Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OXI 3RE, United

• Lane Trevor

  Sir William Dunn School Of Pathology University Of Oxford South Parks Road Oxford Oxi 3re United Kin

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• Chelerythrine Inhibits the Secretory Response of Human Blood Platelets without Specifically Inhibiting Protein Kinase C.

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