Nuclear Galectin-3 Overexpression Inversely Correlates with Lymph Node Metastasis in Lung Adenocarcinomas

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概要

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• Multi-functional galecin-3 is found in the nucleus as well as in the cytoplasm. In order to clarify the role of galectin-3 in progression of lung tumors we here immunohistochemically investigated levels in 300 non-small cell lung cancers (NSCLCs), 164 adenocarcinomas (ACs) and 136 squamous cell carcinomas (SCCs), using a monoclonal antibody, Galectin-3 was found to be overexpressed in the nucleus in 87 (53.0%) and 39 (28.7%) of the ACs and SCCs, respectively, and in the cytoplasm in 57 (34.8%) vs 27 (19.9%) (p=0.004, p<0.001). In ACs, nuclear overexpression inversely correlated with lymph node-metastasis (p=0.049) in association with tendency of cytoplasmic overexpression to progression of clinical stage and linkage to histological malignant grading in ACs. In SCCs no correlation was found between galectin-3 positivity and clinicopathological variables. There was no link in either case with survival duration examined by the Kaplan-Meier method. In conclusion, it seems likely that galectin-3 plays opposite roles in the cytoplasm and nucleus and that down-regulation in latter may be involved in cancer progression in lung adenocarcinoma cases.

• 北里大学の論文
• 2003-10-31

著者

• MATSUI KAZUHIRO

  First Department of Pathology, Toyama Medical and Pharmaceutical University School of Medicine

• Hayashi S

  Department Of Diagnostic Pathology Graduate School Of Medicine And Pharmaceutical Sciences

• Takano Yasuo

  Department Of Diagnostic Pathology Graduate School Of Medical And Pharmaceutical Sciences University

• Ishizawa Shin

  First Department Of Pathology School Of Medicine Toyama Medical And Pharmaceutical University

• MURAI Yoshihiro

  First Department of Pathology, Toyama Medical and Pharmaceutical University

• TAKANO Yasuo

  First Department of Pathology, Toyama Medical and Pharmaceutical University

• Abdel-Aziz Hekmat

  First Department of Pathology, School of Medicine, Toyama Medical and Pharmaceutical University

• Hori Ryota

  First Department of Pathology, School of Medicine, Toyama Medical and Pharmaceutical University

• Hayashi Shinnichi

  First Department of Pathology, School of Medicine, Toyama Medical and Pharmaceutical University

• Cheng Chumei

  First Department of Pathology, School of Medicine, Toyama Medical and Pharmaceutical University

• Tusneyama Koichi

  First Department of Pathology, School of Medicine, Toyama Medical and Pharmaceutical University

• Hori Ryota

  First Department Of Pathology School Of Medicine Toyama Medical And Pharmaceutical University

• Cheng Chumei

  First Department Of Pathology School Of Medicine Toyama Medical And Pharmaceutical University

• Murai Y

  Department Of Diagnostic Pathology Graduate School Of Medicine And Pharmaceutical Science University

• Matsui K

  First Department Of Pathology School Of Medicine Toyama Medical And Pharmaceutical University

• Tusneyama Koichi

  First Department Of Pathology School Of Medicine Toyama Medical And Pharmaceutical University

• Abdel-aziz Hekmat

  First Department Of Pathology School Of Medicine Toyama Medical And Pharmaceutical University

• MATSUI Kazuhiro

  First Department of Pathology, School of Medicine, Toyama Medical and Pharmaceutical University

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