Experimental Studies on the Effect of Hepatoprotective Compounds

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概要

• 論文の詳細を見る

• The hepatopharmacological actions of Prostacyclin, 1-phosphate-4-amino 5-carboxamido-imidazole (AICA-P), Catergen, Silymarin and a thiazolidine compound were investigated by applications in in vitro and in vivo model systems. The usefulness of the in vitro system to screen for potential hepatoprotective agents and to investigate the molecular mechanism of these substances is shown. It was concluded that different patterns of hepatoprotective action were elaborated by the same drug depending on the model system used for testing. PGI_2 and the thiazolidine compound showed remarkable protection in acute liver damage. However PGI_2 circumvented only the CCl_4 induced cellular injury, and was inactive in the galactosamine model system. The induction of cirrhosis could be modified by the simultaneous treatment with PGI_2 or by the thiazolidine compound but the fully developed cirrhosis was not affected. On the contrary AICA-P and Silymarin treatment resulted in reduction of the amount of collagen in cirrhotic liver.

• 東海大学の論文
• 1986-10-17

著者

• Schaff Zsuzsa

  Institute Of Pathology And Experimental Cancer Research Semmelweis Medical University

• Lapis Karoly

  I. Institute Of Pathology And Experimental Cancer Research Semmelweis Medical University

• JENEY Andras

  I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University

• LAPIS Karoly

  Institute of Pathology and Experimental Cancer Research Semmelweis Medical University

• JENEY Andras

  Institute of Pathology and Experimental Cancer Research Semmelweis Medical University

• DIVALD Andras

  Institute of Pathology and Experimental Cancer Research Semmelweis Medical University

• VAJTA Gabor

  Institute of Pathology and Experimental Cancer Research Semmelweis Medical University

• ZALATNAI Attila

  Institute of Pathology and Experimental Cancer Research Semmelweis Medical University

• Jeney Andras

  I. Institute Of Pathology And Experimental Cancer Research Semmelweis Medical University

関連論文

• Glycosaminoglycans as Novel Target in Antitumor Therapy
• Alterations of Glycosaminoglycans in Human Liver and Kidney Tumors
• Experimental Studies on the Effect of Hepatoprotective Compounds

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