Comparative Oral Toxicity of Coenzyme Q_<10> and Its (2Z)-Isomer in Rats : Single and Four-Week Repeated Dose Toxicity Studies

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It has been reported that coenzyme Q_<10> (CoQ_<10>) functions as an electron transfer carrier in mitochondria, and can produce an improvement in heart diseases such as congestive heart failure. Its (2Z)-isomer contains a cis-double bond at the 2-position of the decaprenyl side chain. As the original organic industrial synthesis of CoQ_<10> resulted in a product that contained a small amount of this isomer, the efficacy and safety of CoQ_<10> was determined using CoQ_<10> containing this isomer; however, no toxicity data have been reported for the (2Z)-isomer itself. Thus, we conducted single (2,000mg/kg) and 4-wk repeated (1,000mg/kg) oral dose toxicity studies in rats to compare the toxicological profiles of CoQ_<10> and its (2Z)-isomer. The two compounds displayed similar toxicological profiles, and it was concluded that neither CoQ_<10> nor its (2Z)-isomer produce toxic effects in rats in single or repeated doses.
日本ビタミン学会の論文