卵巣摘出ラットの骨密度に対するスタチン長期投与に関する研究
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概要
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Atorvastatin inhibits synthesis of mevalonate in cholesterol biosynthesis pathway. Statins such as atorvastatin stimulate osteoblast differentiation and enhance mineralization in vitro. The present study was undertaken to investigate the in vivo effect of atorvastatin on bone mineral density (BMD) in ovariectomized (OVX) rats. Atorvastatin, vehicle, 17β-estradiol (E_2) and human parathyroid hormone (1-34) (hPTH(l-34)J were subcutaneously injected four times a week for 8-12 weeks in OVX rats. Atorvastatin (2mg/kg) alone did not alter BMD of the mandible and the lumbar vertebra in OVX rats. The combination of atorvastatin (2mg/kg) and E_2 (10μg/kg) during 12week treatment significantly increased BMD of molar region in the mandible and the lumbar vertebra. Concomitant injections of atorvastatin (2mg/kg) with hPTH (1-34) (1μg/kg) for 8 weeks significantly increased BMD of molar region of the mandible and the lumbar vertebra. These findings demonstrate that chronic administration of atorvastatin augments BMD of trabecular bone-rich regions such as molar portion of the mandible and the lumbar vertebra in OVX rats treated with submaximal dose of E_2 and hPTH (1-34).
- 奥羽大学の論文
- 2005-06-30