日本人男性事業所従業員におけるcommunity periodontal index scores に及ぼす肥満の影響に関する横断的研究

概要

論文の詳細を見る
To analyze the relationship between obesity and periodontal diseases from the epidemiological viewpoint, the present study was conducted on about 2,000 healthy Japanese employed in a large business. Periodontal disease was diagnosed by measuring the Community Periodontal Index (CPI). Compared to those with normal body weight, the odds ratio of obese individuals developing peri-odontal diseases was 1.67. Even after adjusting for age and smoking habits, the ratio was 1.53, showing a significant difference between obese individuals and those of normal body weight. For the mechanism by which obesity becomes involved in the development of periodontal diseases, TNF-a, a cytokine secreted by fat cells, is suspected to be an important factor. While it is manu-factured by monocytic cells among leukocytes and counteracts the adverse state caused by an external force, TNF-a also has an important role in acting against the stresses brought about by conditions such as inflammation and tissue destruction. Because of its action to promote bone resorption, it is understood that TNF-a is involved in the development of periodontal diseases that are characterized by resorption of the alveolar bone.
大阪府立大学の論文
2004-12-27