Molecular Oscillation of Per1 and Per2 Genes in the Rodent Brain : An In Situ Hybridization and Molecular Biological Study

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概要

• 論文の詳細を見る

• The circadian rhythm is originally generated by a transcription-translation basedoscillatory loop where Per1 and Per2 genes locate in its central. In the rat brain,rhythmic expressions of Per1 and Per2 were observed not only in neurons of thehypothalamic suprachiasmatic nucleus (SCN) but also in those of non-SCN regionsincluding the cerebral cortex. The E-box enhancer elements possible to regulatetranscription of Per1 and Per2 genes were highly conserved in rats and mice. WhenE-box-activating transcription factors, CLOCK and BMAL1, were coexpressed, each ofboth proteins showed two molecular forms. The presence of these higher molecularweight forms seems to be correlated with the E-box mediated transcription activation.This mechanism might not be involved in the PER2 mediated suppression of E-box,since adding PER2 did not change the content of the higher molecular forms ofCLOCK and BMAL1.

• 神戸大学の論文

著者

• Matsui Daisuke

  Kobe University Graduate School Of Mecicine

• Okamura Hitoshi

  Kobe University Graduate School Of Mecicine

• Takekida Seiichi

  Kobe University Graduate School of Mecicine

関連論文

• Transparent Biosensor with Micro Channel Array for Optical and Electrophysiological Detection of Luciferin-Luciferase Reaction
• Molecular Signals of Mammalian Circadian Clock
• Molecular Oscillation of Per1 and Per2 Genes in the Rodent Brain : An In Situ Hybridization and Molecular Biological Study

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