Identification and Allelic Frequencies of a Novel Polymorphism in the Human Ku70 Gene

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概要

• 論文の詳細を見る

• Recent study demonstrated that Ku70 is involved in not only DNA double-strand break repair and V(D)J recombination but also tumor development. In the course of analyzing the Ku70 gene for mutations in colorectal cancer, we identified a novel, rare polymorphism, an "AT" deletion in the 3'-untranslated region, and analyzed its allelic frequencies in Japanese patients with colorectal cancer and healthy individuals. The allelic frequencies were 0.026 and 0.027, respectively. No significant difference was observed between them; however, this polymorphism will be useful for genetic studies not only of cancers but also of autoimmune disorders.

• 関西学院大学の論文

著者

• Karasawa Akira

  Kwansei Gakuin University

• Kobayashi Terutada

  Saitama Cancer Center

• Ogata Masao

  Saitama Cancer Center

• Nishikawa Satoshi

  Kwansei Gakuin University

• Akagi Kiwamu

  Biomedical Science Saitama Cancer Center Research Institute

• Yagura Tatsuo

  Biological Science Kwansei Gakuin University

• ROY Bidyut

  Kwansei Gakuin University

• YAMAGUCHI Kensei

  Saitama Cancer Center

関連論文

• Identification and Allelic Frequencies of a Novel Polymorphism in the Human Ku70 Gene
• Germline Mutation of Dihydropyrimidine Dehydrogenese Gene among a Japanese Population in Relation to Toxicity to 5-Fluorouracil

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