Comparison of Nifekalant and Lidocaine for the Treatment of Shock-Refractory Ventricular Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
Background Although nifekalant is a class in antiarrhythmic agent without negative inotropic activity, its effect in patients with shock-refractory ventricular fibrillation remains unclear. Methods and Results Patients who had an out-of-hospital cardiac arrest with ventricular fibrillation that persisted after 3 shocks from an external defibrillator, intravenous epinephrine, and another shock were retrospectively studied. The patients received lidocaine from January 1997 through June 2001 and nifekalant from July 2001 through December 2004. Short-term survival rates (survival to hospital admission and 24-h survival) were compared between the groups. The study group comprised 120 patients (mean age: 62±16 years): 55 received nifekalant and 65 received lidocaine. Age, sex, history of ischemic heart disease, whether arrest was witnessed or not and time to arrival at the hospital did not differ significantly between the groups. As compared with lidocaine, nifekalant was associated with significantly higher rates of survival to hospital admission (67% vs 37%, p<0.001) and 24-h survival (53% vs 31%, p=0.01). Multivariate analysis showed that treatment with nifekalant and early initiation of cardiopulmonary resuscitation were independent predictors of 24-h survival. Conclusions As compared with lidocaine, nifekalant may improve short-term survival in patients with out-of-hospital cardiac arrest due to shock-refractory ventricular fibrillation.
- 社団法人日本循環器学会の論文
- 2006-03-20
著者
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KOSUGE Masami
Division of Cardiology, Yokohama City University Medical Center
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KIMURA Kazuo
Division of Cardiology, Yokohama City University Medical Center
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HIBI Kiyoshi
Division of Cardiology, Yokohama City University Medical Center, Yokohama City University Graduate S
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EBINA Toshiaki
Division of Cardiology, Yokohama City University Medical Center, Yokohama City University Graduate S
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SUMITA Shinichi
Division of Cardiology, Yokohama City University Medical Center
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Suzuki Noriyuki
Division Of Cardiology St. Marianna University School Of Medicine
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Takanashi Yoshinori
Division Of Cardiology Yokohama City University Medical Center
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Ebina Toshiaki
横浜市立大学附属市民総合医療センター 心臓血管センター
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Kosuge Masami
Division Of Cardiology Yokohama City University Medical Center
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Hibi Kiyoshi
Division Of Cardiology Yokohama City University Medical Center
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Sumita S
Division Of Cardiology Yokohama City University Medical Center
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Sumita Shinichi
横浜市立大学附属市民総合医療センター 心臓血管センター
-
Sumita Shinichi
Second Department Of Internal Medicine Yokohama City University Hospital
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Minami Kazutoshi
Yokohama City University Medical Center
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Kohagura Kentaro
琉球大学 第三内科
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Toyama Hideshi
Yokohama City University Medical Center
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Tahara Yoshio
Division Of Cardiology Yokohama City University Medical Center
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Ebina Toshiaki
Division Of Cardiology Yokohama City University Medical Center
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Suzuki Noriyuki
Yokohama City University Medical Center
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Moriwaki Yoshihiro
Yokohama City University Medical Center
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Kosuge Takayuki
Yokohama City University Medical Center
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Sugiyama Mitsugi
Yokohama City Medical Control Conference
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Sumita Shinichi
Division Of Cardiology Yokohama City University Medical Center
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Kimura Kazuo
Division Of Cardiology Yokohama City University Medical Center
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Umemura Satoshi
Division Of Cardiology Yokohama City University Medical Center
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Toyama Hideshi
Division of Cardiology, Yokohama City University Medical Center
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Kosuge Takayuki
Division of Critical Care and Emergency Medicine, Yokohama City University Medical Center
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Moriwaki Yoshihiro
Division of Critical Care and Emergency Medicine, Yokohama City University Medical Center
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Sugiyama Mitsugi
Division of Critical Care and Emergency Medicine, Yokohama City University Medical Center
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Kikuchi Miyako
Yokohama City University School Of Medicine Cardiovascular Center
-
Minamizawa Kousuke
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Suzuki Shinichi
横浜市立大学 医学部心臓血管外科
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Sugiyama Mitsugi
Division Of Critical Care And Emergency Medicine Yokohama City University Medical Center
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