5)マウスGVHDモデルと炎症性皮膚疾患(<シンポジウム>皮膚粘膜の免疫と疾患)
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概要
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Human inflammatory cutaneous diseases include immunologically induced diseases, e. g. contact dermatitis, drug eruption, cutaneous GVHD. Although many murine experimental models mimicking human immunological events have been reported, there have been few murine models manifesting inflammatory cutaneous lesions. We previously reported that systemic GVHD in athymic nude mice involved apparent cutaneous lesions like human cutaneous GVHD. Our studies suggested that dendritic epidermal T cells (DETC) might play an important role for regulation of murine cutaneous GVHD. Here, we will demonstrate DETC-dependence of cutaneous rigidity to GVHD.
- 新潟大学の論文
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