<綜説>発生期脳における未分化細胞の移動経路と動態

概要

論文の詳細を見る
The great majority of glial cells are generated in the perinatal period from progenitors in the subventricular zone (SVZ). We investigated the migration of progenitors from the neonatal (postnatal day 0,P0) rat forebrain SVZ by labeling them in vivo with a retrovirus encoding green fluorescent protein gene, and monitoring their movements by time-lapse video microscopy in P3 slice preparations. Cells migrated radially and tangentially after emigration into white matter, cortex, and striatum. During migration, elongation of the leading process and nuclear translocation were independent or linked. Orthogonal turning involved either cessation of the cell body movement and formation of a new leading process, or continuous cell body movement and bending of the leading process. Some cells migrated tangentially through the corpus callosum along the unmyelinated axon fascicules, rather than the radial fibers. The dynamic behavior of progenitors may reflect local tissue architecture and contribute to the widespread distribution of glia.
新潟大学の論文
2002-03-10