心停止ドナー心のviability予測に関する実験的研究 : 組織誘電特性と硬度計を用いた評価法
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Purpose : Easy and continuous evaluation system of the viability of non-beating heart graft has not been established. In our previous studies, it revealed that the dielectric properties represented with tanδm reflected the structural and physiological changes of the cold preserved heart graft. In this study, we investigated the correlations between the dielectric properties and the myocardial tactile of non-beating heart graft during warm ischemia and cold preservation. We also investigated the effect of prostaglandin E1 (PGE1) on these predictors of myocardial viability. Materials and Methods : Following cardiac arrest induced by asphyxia, the cardiac graft was exposed for 20-minute warm ischemia and 60-minute cold preservation with and without the administration of PGE1. The tanδm and the myocardial tactile (Δ F) were measured using an impedance analyzer and a tactile sensor system, respectively. Results : Tanδm of the heart graft without PGE1 reduced gradationally. However, that of the heart graft with PGE1 showed the gradational reduction with the peak at 7 minutes after initiation of warm ischemia. Δ tanδm was subtracted the value at the initiation of warm ischemia from that of specific tanδm. Δ tanδm with PGE1 was higher than that without PGE1 (p<0.001). Delta Δ F was subtracted the value at the initiation of warm ischemia from that of specific Δ F. Delta Δ F with PGE1 was lower than that without PGE1 (p<0.001). There was the significant correlation between Δ tanδm and delta Δ F. Conclusion : Δ tanδm with PGE1 was higher than that without PGE1. Delta Δ F with PGE1 was lower than that without PGE1. The significant correlation between Δ tanδm and delta Δ F was also found. Our results suggested that myocardial tactile could represent the viability of non-beating heart graft. And also suggested that PGE1 could preserve the myocardial viability.
- 2003-03-31