Altered Electrophysiological Expression of Synaptic Plasticity andInfrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats

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β-amyloid-filled osmotic minipumps were used for 14-day intracerebroventricular infusion in rats, followed by routine housing for >1 year. Extracellular recording of evoked potentials from cortical slices from β-amyloid-treated animals showed abnormal elicitation of long-term depression. Whereas no statistically significant difference could be found between β-amyloid-treated and control groups in cortical membrane protein kinase C activity, the use of infrared spectroscopy provided some evidence of alterations in the structure of tissue proteins and an increase in the content of acidic amino acids. The results suggest that the combination of β-amyloid infusion and normal aging may result in an animal model possessing certain functional and structural features useful for study, which may help illuminate some of the etiologies relevant to Alzheimer's disease.
新潟大学の論文