マウスにおけるグルコースの摂食抑制作用に対する絶食の影響(西九州大学 I.健康栄養学科)

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We investigated the effect of starvation on the glucostatic mechanism involved in the regulation of feeding. An intraperitoneal injection of glucose resulted in significant suppression of feeding in mice deprived of food for 24 hours. Food deprivation for 48 hours reduced the glucose-induced inhibition of feeding, while starvation for 72 hours eliminated this inhibitory effect entirely. The peak rise in blood glucose was reduced, although not significantly, when glucose was injected in mice deprived of food for 48 hours. This reduction in peak blood glucose levels reached statistical significance when glucose was injected in mice deprived of food for 72 hours. These results indicate that the glucostatic mechanism of feeding regulation is attenuated by serious food deprivation.
西九州大学の論文
2004-03-01