Odontogenic Keratocyst, Orthokeratinized Odontogenic Cyst and Epidermal Cyst: An Immunohistochemical Study Including Markers of Proliferation, Cytokeratin and Apoptosis Related Factors

概要

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Objective: There are microscopic similarities among odontogenic keratocyst (OKC), orthokeratinized odontogenic keratocyst (OOC) and epidermal cyst (EDC). This study was to compare with cell proliferation, cell differentiation and apoptosis related factors in OKC, OOC and EDC in order to clarify the characters and category of three hitstopathologically similar cysts. Material and Methods: Fourteen cases of OKC, nine cases of OOC an eighteen cases of EDC were examined immunohistochemically using antibodies against Ki-67, cytokeratins (CK7, 10, 10/13, 17, 18, 19, 20) and apoptosis related factors (bc1-2 and Bax). Results: Ki-67 labeling index in OKC was statistically higher than that in OOC and EDC (p<0.05). And that in OOC was higher in EDC (p<0.05). In OKC, CKs and bc1-2 expression patterns were different from OOC and EDC, while both OOC and EDC showed similar reactivity with CKs and bc1-2. Conclusions: The present results suggested that OKC had high cellular proliferation and was relatively low differentiation as compare with OOC and EDC. In addition, there was participation of apoptosis suppressor in OKC. The character of OOC occupied an intermediate position between OKC and EDC. Therefore, it was possible to consider OOC as a distinct entity from OKC. EDC had the lowest cellular activity in the three cysts and it was comparativel maturated lesion.