Role of Proopiomelanocortin Mediating Leptin's Action in the Rat Hypothalamus

スポンサーリンク

概要

• 論文の詳細を見る

• Proopiomelanocortin (POMC; the precursor molecule of ACTH) neurons may be plausible targets for the action of leptin. We examined whether ACTH neurons contain Fos immunoreactivity (ir) after intraperitoneal (i.p.) injection of leptin. In addition, we characterized the hypothalamic neurons activated by intracerebroventricular (i.c.v.) infusion of melanocortin receptor agonist MT- n (Ac-Nle^4-c[Asp^5, _D-Phe^7, Lys^<10>] α-MSH-(4-10)-NH_2). Approximately 27.0% of ACTH-positive neurons in the arcuate nucleus coexpressed Fos after i.p. leptin administration. The proportion of oxytocin neurons coexpressing Fos was 26.7% in the supraoptic nucleus and 21.2% in the paraventricular nucleus after i.c.v. MT-II administration. Leptin indirectly regulates food intake by upregulating POMC expression and increasing melanocortins in the hypothalamus, thereby activating melanocortin signaling in oxytocin neurons of the hypothalamus.

• 香川県立保健医療大学の論文
• 2004-03-31

著者

• Niimi Michio

  Department Of Medical Technology Faculty Of Health Sciences Kagawa Prefectural College Of Health Sci

• Niimi Michio

  Department Of Medical Technology Kagawa Prefectural College Of Health Sciences

関連論文

• Role of Proopiomelanocortin Mediating Leptin's Action in the Rat Hypothalamus
• Effects of Short- and Long-Term Dexamethasone Treatment on Growth and Growth Hormone (GH)-Releasing Hormone (GRH)-GH-Insulin-Like Growth Factor-I Axis in Conscious Rats
• Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia
• Epidemiologic Analysis of Metabolic Syndrome and Chronic Kidney Disease on General Health Examination in Japanese women

スポンサーリンク