Relationship between Permeability and Endothelial Cell Morphology in Rat Aortae

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概要

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• The permeability and endothelial cell morphology in rat aortae were measured. Using FITC-albumin as a tracer, the permeability was measured on the lateral sides of ascending aota (immediately before the brachiocephalic artery, A), aortic arch (immediately after the left subclavian artery, C) and thoracic aorta (E) , and on their medial sides, B, D and F, respectively. By silver staining endothelial cell morphology was observed in the same portions where the permeability was measured. The permeabilities in A and B of the ascending aorta were higher than those of the aortic arch and thoracic aorta. The cell morphology in A and B was almost the same as in other portions. However, the deviation values of the cell orientation to the axis of the blood vessel in A and B were higher than those in other portions. These results indicate that a complex blood flow in the ascending aorta affected the orientation of endothelial cells and might induce the changes in the permeability through endothelial cells.

• 一般社団法人日本機械学会の論文
• 1999-09-15

著者

• SATO Masaaki

  Graduate School of Pharmaceutical Sciences, Chiba University

• Ogawa Yoshinobu

  Graduate School Of Mechanical Engineering Tohoku University

• Kataoka Noriyuki

  Graduate School Of Mechanical Engineering Tohoku University

• TAKEDA Kouichiro

  Graduate School of Mechanical Engineering, Tohoku University

• Takeda Kouichiro

  Graduate School Of Mechanical Engineering Tohoku University

• Sato Masaaki

  Graduate School Of Agricultural Science Tohoku University

• Sato Masaaki

  Graduate School Of Mechanical Engineering Tohoku University

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