Generation Mechanism of Vascular Endothelial Chained Vesicles and Transendothelial Channel

概要

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Vascular endothelial cell vesicles are attached to both luminal and abluminal surfaces of the endothelium and contribute to the transport of specific macromolecules between the external environment and the cell. The vesicles have mostly flask-like or chained bead-like shapes, while they appear free within the cytoplasm. The existence of a transendothelial channel, which is considered to be involved in specific transport systems, is also reported. In this study, the generation mechanism of vascular endothelial chained vesicles and the transendothelial channel is theoretically investigated based on a method proposed by J.C. Luke (1982). A system of nonlinear differential equations is derived according to the variational principle and is reduced to a two-point boundary value problem. The equations are solved using the shooting method along with the Newton-Raphson and Runge-Kutta methods. The computed shape of the vesicle suggests that the chained vesicles and the cylindrical transendothelial channel are the most dynamically stable shape which can be formed in vascular endothelial cells.
一般社団法人日本機械学会の論文
1999-09-15