Geometric Optimization for Non-Thrombogenicity of a Centrifugal Blood Pump through Flow Visualization(Reviewed Papers Accepted for Publication in this Special Issue)(Special Issue on Bioengineering)

概要

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A monopivot centrifugal blood pump, whose impeller is supported with a pivot bearing and a passive magnetic bearing, is under development for implantable artificial heart. The hemolysis level is less than that of commercial centrifugal pumps and the pump size is as small as 160 mL in volume. To solve a problem of thrombus caused by fluid dynamics, flow visualization experiments and animal experiments have been undertaken. For flow visualization a three-fold scale-up model, high-speed video system, and particle tracking velocimetry software were used. To verify non-thrombogenicity one-week animal experiments were conducted with sheep. The initially observed thrombus around the pivot was removed through unifying the separate washout holes to a small centered hole to induce high shear around the pivot. It was found that the thrombus contours corresponded to the shear rate of 300 s^-1 for red thrombus and 1 300 - 1 700 s^-1 for white thrombus, respectively. Thus flow visualization technique was found to be a useful tool to predict thrombus location.
一般社団法人日本機械学会の論文
2002-12-15