Recent Advances in Cartilage Tissue Engineering : From the Choice of Cell Sources to the Use of Bioreactors(Proceedings of the Switzerland-Japan Workshop on New Directions in Cellular and Tissue Biomechanics)(Special Issue on Bioengineering)
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概要
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Grafting engineered cartilage tissues represents a promising approach for the repair of joint injuries. Recent animal experiments have demonstrated that tissues engineered by culturing chondrocytes on 3D scaffolds in bioreactors provide functional templates for orderly repair of large osteochondral lesions. To date, however, a reproducible generation of uniform cartilage tissues of predefined size starting from adult human cells has not been achieved. In this paper we review some of the recent advances and challenges ahead in the identification of appropriate (i) cell sources, (ii) bioactive factors, (iii) 3D scaffolds and (iv) bioreactors for human cartilage tissue engineering. We also present an example of how integrated efforts in these different areas can help addressing fundamental questions and advancing the field of cartilage tissue engineering towards clinical use. The presented experiment demonstrates that human nasal chondrocytes are responsive to dynamic loading and thus could be further investigated as a cell source for implantation in a joint environment.
- 一般社団法人日本機械学会の論文
- 2002-12-15
著者
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Martin Ivan
Departments Of Surgery And Of Research University Hospital Basel
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DEMARTEAU Olivier
Departments of Surgery and of Research, University Hospital Basel
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BRACCINI Alessandra
Departments of Surgery and of Research, University Hospital Basel
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Demarteau Olivier
Departments Of Surgery And Of Research University Hospital Basel
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Braccini Alessandra
Departments Of Surgery And Of Research University Hospital Basel