Three New Podocarpane-Type Diterpenoids from Callus of Securinega suffruticosa

概要

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Three new podocarpane-type diterpenoids, 3β, 12-dihydroxy-13-methyl-6, 8, 11, 13-podocarpatetraen (1), 3β, 12-dihydroxy-13-methyl-5, 8, 11, 13-podocarpatetraen-7-one (2), and 1-(7-hydroxy-2, 6-dimethyl-1-naphthyl)-4-methyl-3-pentanone (3) (20(10→5)-abeo-4, 5-seco-5(10), 6, 8, 11, 13-podocarpapentaen-3-one) were isolated from callus of Securinega suffruticosa. The structures were elucidated by spectroscopic methods. Compounds 1, 2, and 3 showed cytotoxic activity against five human cancer cell lines (A549, BEL 7402, BGC-823, HCT-8, A2780).
公益社団法人日本薬学会の論文
2005-12-01