Formulation and Physicochemical Characterization of Microemulsion System Using Isopropyl Myristate, Medium-Chain Glyceride, Polysorbate 80 and Water

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概要

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• The phase behavior of the system isopropyl myristate/medium-chain glyceride/polysorbate 80/water forming both w/o and o/w microemulsions has been studied to develop microemulsion comprising of pharmaceutical excipients. The pseudo-ternary phase diagrams with large monophasic zones and gel formation were realized and several compositions were identified in the phase diagram for rheological, dynamic light scattering (DLS) and calorimetric measurements. The identified systems at different temperatures behaved as Newtonian fluid and the activation parameters for their viscous flow were evaluated. From DLS measurements, hydrodynamic diameter, polydispersity and diffusion coefficient of the microheterogeneous dispersions were determined. The free energy, enthalpy and entropy of solution of the w/o and o/w microemulsions were determined from calorimetric measurements.

• 公益社団法人日本薬学会の論文
• 2005-12-01

著者

• Subramanian Natesan

  Department Of Pharmaceutical Engineering And Technology School Of Engineering And Technology Bharath

• GHOSAL Saroj

  Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University

• Moulik Satya

  Centre For Surface Science Department Of Chemistry Jadavpur University

• Ghosal Saroj

  Division Of Pharmaceutics Department Of Pharmaceutical Technology Jadavpur University

• ACHARYA Asis

  Centre for Surface Science, Department of Chemistry, Jadavpur University

• Acharya Asis

  Centre For Surface Science Department Of Chemistry Jadavpur University

関連論文

• Formulation Design of Self-Microemulsifying Drug Delivery Systems for Improved Oral Bioavailability of Celecoxib(Biopharmacy)
• Formulation and Physicochemical Characterization of Microemulsion System Using Isopropyl Myristate, Medium-Chain Glyceride, Polysorbate 80 and Water

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