Endothelin-1 Receptor Antagonist BQ123 Prevents Pulmonary Artery Hypertension Induced by Low Ambient Temperature in Broilers(Pharmacology)

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概要

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• Evidence has indicated that endothelin-1 is related to the pathogenesis of hypertension. To characterize the role of endothelin-1 (ET-1) in the development of pulmonary hypertension syndrome in broilers, the blockade effect of ETA receptor (ET_A) antagonist, BQ123, on blood pressure in experimental models of pulmonary hypertension was examined. Birds were locally anesthetized and instrumented with venous catheters for pulmonary arterial pressure (PAP) and right ventricular pressure (RVP), followed by packed cell volume (PCV) and Ascites heart index (AHI) measured, after exposed to low ambient temperature for 7 or 14d. In treated groups, BQ123 (0.4 or 2.0μg/kg each time, 2 times a day), administered in abdominal cavities for 7 or 14d during birds kept in low ambient temperature, prevented both PAP and RVP increasing, especially the high dose BQ123 lowered PAP and RVP to normotensive levels as that in control under normal temperature, whereas significant increases (p<0.05) were found in the two parameters of broilers in both untreated and saline treated group under low ambient temperature compared with those of birds in control. Furthermore, there was also a reduction in low ambient temperature-induced right ventricular hypertrophy in the groups administered BQ123. The preventive effect of BQ123 suggests that ET-1 is associated with the development of broilers' pulmonary hypertension, which leads to the development of ascites, and BQ123 can prevent the occurrence of pulmonary hypertension.

• 公益社団法人日本薬学会の論文
• 2005-12-01

著者

• Chen Yue

  National Natural Science Foundation Of China

• Yang Ying

  Division Of Electronic And Information Engineering Graduate School Of Technology Tokyo University Of

• QIAO Jian

  Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University

• WU Zhenlong

  Department of Animal Physiology, College of Biological Sciences, China Agricultural University

• GAO Mingyu

  Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University

• OU Deyuan

  Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University

• WANG Huiyu

  Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University

• Ou Deyuan

  Division Of Basic Veterinary Medicine College Of Veterinary Medicine China Agricultural University

• Qiao Jian

  Division Of Basic Veterinary Medicine College Of Veterinary Medicine China Agricultural University

• Gao Mingyu

  Division Of Basic Veterinary Medicine College Of Veterinary Medicine China Agricultural University

• Wang Huiyu

  Division Of Basic Veterinary Medicine College Of Veterinary Medicine China Agricultural University

• Wu Zhenlong

  Department Of Animal Physiology College Of Biological Sciences China Agricultural University

• Yang Ying

  State Key Laboratory Of Animal Nutrition College Of Animal Science And Technology China Agricultural

関連論文

• Endothelin-1 Receptor Antagonist BQ123 Prevents Pulmonary Artery Hypertension Induced by Low Ambient Temperature in Broilers(Pharmacology)
• Synapse Effect of Waveguide Modulator with a Nematic Liquid Crystal Cladding for Optical Neural Computing
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