In Vivo Modulation of Signaling Factors Involved in Cell Survival

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概要

• 論文の詳細を見る

• In vivo expression of cell survival factors protein kinase C (PKC), nuclear factor κB (NFκB), and extracellular signal-regulated kinase (Erk), which may contribute to the development of radioresistance following radiotherapy, was looked for. Their modulation with natural compounds (curcumin, rutin or nicotinamide) was attempted in mice bearing a serially transplanted fibrosarcoma. Expression of protein kinase C was isoform specific. No translocation of any of the isozymes was noticed following γ-irradiation as has been reported elsewhere. None of the isoforms could be significantly inhibited by the modulators. However, significant inhibition of radiation-induced ERK and NFκB was observed with both curcumin and nicotinamide. Therefore we conclude that use of inhibitors of MAP kinases or NFκB may be a more promising strategy to enhance tumour cell killing or to prevent the development of radioresistance during radiotherapy.

• 日本放射線影響学会の論文

著者

• Krishna Malini

  Radiation Biology And Health Sciences Division Bhabha Atomic Research Centre Trombay

• MITRA Anirban

  Radiation Biology and Health Sciences Division Bhabha Atomic Research Centre Trombay

• Kumar Mitra

  Radiation Biology And Health Sciences Division Bhabha Atomic Research Centre Trombay

関連論文

• Differential Activation of Kinases in Ex Vivo and In Vivo Irradiated Mice Lymphocytes
• In Vivo Modulation of Signaling Factors Involved in Cell Survival

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