Effects of Concentrated Ambient Particles on Heart Rate Variability in Spontaneously Hypertensive Rats

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概要

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• In the present study, the cardiovascular toxicity of PM_<2.5> was determined in spontaneously hypertensive (SH) rats using the standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences of adjacent normal-to-normal intervals (RMSSD) as outcome measurements. Four SH rats implanted with radiotelemetry transmitters were repeatedly exposed to concentrated PM_<2.5> in nose-only exposure chambers. Gravimetric analysis revealed the mean post-concentrating mass concentration of particles during the 5h of exposure was 202μg/m^3. Using each animal as its own control and linear mixed-effects model, to adjust for circadian nature and individual differences, we found that SDNN decreased by 15% initially then gradually decreased to 60% of the initial value at the end of exposure. Our results indicate that concentrated PM_<2.5> may decrease SDNN on SH rats during PM exposure. The study also showed that SDNN is more sensitive to PM induced effects than RMSSD.

著者

• Chan Chang-chuan

  Institute Of Occupational Medicine And Industrial Hygiene College Of Public Health National Taiwan U

• WANG Peng

  Graduate Institute of Environmental Engineering, National Central University

• Chang Chuen-Chau

  Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University

• Hwang Jing-Shiang

  Institute of Statistical Science, Academia Sinica, National Central University

• HU Tsuey

  Institute of Statistical Science, Academia Sinica, National Central University

• CHENG Tsun

  Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University

• CHANG Chuen

  Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University:Department of Anesthesiology, China Medical College Hospital

• HWANG Jing

  Institute of Statistical Science, Academia Sinica, National Central University

• CHAN Chang

  Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University

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• Effects of Concentrated Ambient Particles on Heart Rate Variability in Spontaneously Hypertensive Rats

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