CGRP, PACAP and GAL mRNA expression in the trigeminal and cervical dorsal root ganglia after experimental inflammation of the rat temporomandibular joint

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Pain emanating from the temporomandibular joint (TMJ) is frequently encountered in clinical practice and often involves inflammatory processes. Neuropeptides are believed to mediate some aspects of the inflammatory responses. In the present study, we have tried to evaluate the possible involvement of some neuropeptides in TMJ inflammation. The expression of calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase activating peptide (PACAP) and galanin (GAL) mRNAs in the trigeminal and dorsal root ganglia (DRG) at cervical level were quantified after induction of inflammation in the rat TMJ induced by an unilateral injection of Freund's adjuvant. We found that CGRP, PACAP and GAL mRNAs were upregulated in the trigeminal ganglion and DRG at 3rd cervical level already at 12 hours after the injection. The results indicate that there is an upregulation of the expression of several genes coding for neuropeptides in the trigeminal ganglion and DRG upon an experimental inflammation of the rat TMJ, which suggests that neuropeptides may play an important role in inflammatory responses.
日本矯正歯科学会の論文