Matrix Metalloproteinases in Joint Destruction in Rheumatoid Arthritis(<Special Issue>Pathogenesis of the Collagen Disease and Extracellular Matrix Reseaches)
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概要
- 論文の詳細を見る
The progressive destruction of articular cartilage is one of the hallmarks of rheumatoid arthritis(RA). Although different classes of proteolytic enzymes appear to be involved, cartilage degradation has been attributed mainly to the action of matrix metalloproteinases (MMPs), which are a family of enzymes that collectively degrade all components of the extracellular matrix. MMPs mediate irreversible matrix degradation and subsequent joint destruction in RA. This review describes the members of MMP family,the structure of MMPs, and the activation mechanism of proMMPs, and discusses the regulation of MMP expression and the pathologic implication in joint destruction in RA.
- 日本結合組織学会の論文
- 2004-12-25
著者
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Yasuda Tadashi
Department Of Sports Medicine Faculty Of Sports Budo &health Studies Tenri University
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Yasuda Tadashi
Department Of Orthopaedic Surgery Kyoto University Graduate School Of Medicine
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Yasuda Tadashi
Department Of Internal Medicine Honjo Daiichi Hospital
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安田 義
Department of Sports Medicine, Faculty of Sports, Budo, &Health Studies Tenri University
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