MMP and ADAM in Rheumatoid Arthritis(<Special Issue>Pathogenesis of the Collagen Disease and Extracellular Matrix Reseaches)
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概要
- 論文の詳細を見る
Rheumatoid arthritis (RA) is characterized by chronic proliferative synovitis, in which various proteinases are produced and attack the articular cartilage. Among the proteinases, matrix metalloproteinases (MMPs) may play a major role in the degradation of the extracellular matrix macromolecules in RA cartilage. However, recent studies have demonstrated the possible involvement of MMP-related metalloproteinases, i.e. a disintegrin and metalloproteinases (ADAMs) in the degradation. In the presentarticle, we review recent information about the MMP and ADAM families and their implications for cartilage destruction in RA.
- 日本結合組織学会の論文
- 2004-12-25
著者
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Okada Yasunori
Department of Pathology, Keio University School of Medicine
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谷田部 拓
慶應義塾大学病理学教室
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Okada Yasunori
Department Of Pathology School Of Medicine Keio University
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YATABE Taku
Department of Pathology, School of Medicine, Keio University
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Okada Yasunori
Department Of Mathematics And Informatics Faculty Of Science Chiba University
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Yatabe Taku
Department Of Orthopedic Surgery Keio University
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Okada Yasunori
Department Of Internal Medicine Iii Faculty Of Medicine Kagoshima University
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