Biologic Roles of Cytokines in Tissue Fibrosis and Vascular Damage in Systemic Sclerosis(<Special Issue>Pathogenesis of the Collagen Disease and Extracellular Matrix Reseaches)

概要

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Systemic sclerosis (SSc) is characterized by a complex interaction of immunologic abnormalities, including autoantibody production, T-cell activation, vascular damage, and increased collagen production by fibroblasts. Tissue fibrosis, resulting from the excessive accumulation of matrix proteins, is the particular hallmark of SSc. An understanding of the pathophysiology of fibroblast activation has been a subject of studies involving the pathways that lead to tissue fibrosis in SSc. In particular, cytokine or growth factor signaling was shown to modulate key regulatory pathways that are involved in synthesis of matrix components by fibroblasts. Additionally, chemical mediators contributed to injury of endothelial cells in SSc. This article discusses the biologic functions of cytokines that contribute to fibrosis and vascular damage in SSc.
日本結合組織学会の論文
2004-12-25