(<特集>肝臓領域)

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概要

• 論文の詳細を見る

• Hepatic stellate cells lie in a three-dimensionally distributed extracellular matrix(ECM)of the perisinusoidal space.The three-dimensional structure of the ECM regulates the proliferation, morphology, and functions of the stellate cell.In this review, morphology of sites of adhesion between extracellular matrix and hepatic stellate cells is described.Hepatic stellate cells cultured in polystyrene dishes spread well.The cells cultured on or in type I collagen gel elongate their cell bodies and become slender.The cellular processes directly adhere to the collagen fibers.The cells in type I collagen gel form a large number of adhesive structures that resembled focal adhesions.Each adhesive area forms a face but not a point.Cell-surface adhesion molecules for the ECM are localized on the surface of the cells.Three-dimensional ECM component regulates the morphology of hepatic stellate cells by the three-dimensional adhesive structure through integrins.

• 日本結合組織学会の論文

著者

• Imai Katsuyuki

  秋田大学 解剖

関連論文

• (肝臓領域)

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