消化管創傷治癒 : 消化性潰瘍修復および吻合創治癒(<特集>外科領域)

概要

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The gastrointestinal(GI)tract respond to a variety of injuries.The most encountered situations are peptic ulceration and anstomotic healing associated with resection of the gut.This paper reviews area of peptic ulceration repair and anastomotic healing.The Trefoil peptides are shown to play an important role in mucosal healing as well as epidermal growth factor and tarnsforming growth factor-α.An omental implantation(patch), a surgical technic that repairs a perforated gastric and/or doudenal ulcer.A rat study of omental implantation(OI)into ulcer induced by acetic acid showed OI accerelated the healing without scar formation.Healing pattern of the stapled GI anastomosis and hand sewn suture are examined.End-on type anastomosis of colon healed by first intention, whereas stapled esophago-jejunal anastomosis healed by secondary intention.Future advancement of GI healing is expected to manipulate the struggle between collagen synthesis and breakdown by using matrix-metalloproteinases inhibitors.
日本結合組織学会の論文