Fibulins : Microfibrillar Proteins

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概要

• 論文の詳細を見る

• Fibulins are extracellular proteins which belong to the family of proteins containing long tandem arrays of epidermal growth factor(EGF)-like modules with a consensus sequence for calcium binding. At present two fibulins are known, fibulin-1 and fibulin-2. Fibulin-1 is secreted as a monomer and has a dumbell-like structure about 33nm long. Recombinant expression of fibulin-2 demonstrated its assembly into elongated dimers which are connected by a disulfide bridge. Fibulins bind several extracellular matrix proteins(fibronectin, nidogen, fibrillin etc.), which in most cases requires calcium. They are expressed in a wide variety of tissues already during embryonic development and assemble into extracellular microfibrils.

• 日本結合組織学会の論文
• 1998-03-25

著者

• 佐々木 隆子

  マックスプランク研

• 佐々木 隆子

  マックス・プランニング研究所生化学部門

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• Fibulins : Microfibrillar Proteins

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