Candida albicansの対数増殖期における代謝阻害と発芽管形成

概要

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The mechanism for yeast-mycelial transition in the dimorphic pathogenic fungus Candida albicans is closely related with the pathogenesis and morphogenesis. In Candida albicans, mid-exponential phasecells growing in the budding form cannot be immediately induced to form mycelia. However, the organism pretreated by starvation form mycelia. Yeast growth of mid-exponential phase cells was inhibited by addition of metabolic inhibitors such as hydroxyurea, and deoxyglucose to the growth medium. Metabolic inhibition may be the first step necessary for yeast-mycelial transition.
福岡歯科大学学会の論文
1997-03-31