Candida albicansのgerm tube形成におけるプロリンとN-アセチルグルコサミンの関係

概要

論文の詳細を見る
Metabolism of proline during germ tube formation in C.albicans was examined using ATPC and LTPC medium. The result obtained were as follows. 1. About 70% of the cells formed germ tubes by replacing proline in ATPC medium with glutamic acid, alanine, β-alanine, glutamine, N-acetylglucosamine, glucose, galactose, fructose, mannose, maltose or sucrose. 2. The uptake of ^<14>C-proline of the cells was reduced to 50% when proline was replaced with glutamic acid, α-ketoglutaric acid, succinic acid, glucose or N-acetylglucosamine in ATPC medium. 3. More than 90% of the cells formed germ tubes by replacing proline in the LTPC medium with various substances tested. 4. Although N-acetylglucosamine reduced the uptake of ^<14>C-proline by the cells to 50% in LTPC medium, other substances used did little. 5. Studies using ^3H-proline and ^<14>C-glutamic acid indicated that both amino acids were entered into the TCA cycle and metabolized to glucosamine and an unidentified substance with the Rf value of 0.85 when the cells were cultured in ATPC and LTPC media.
福岡歯科大学学会の論文
1996-06-30