歯周炎病巣局所におけるCD4^+CD45RA^+T細胞サブポピュレーションの動態

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概要

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• Immunological mechanisms have been implicated in the pathogenesis of human periodontal diseases. The histopathological works suggested that periodontal lesions are induced by the immunoregulatory imbalance of T cells which have been recognized to play a central role in the immunoregulatory network at both loeal and systemic levels. In the previous studies of subjects with periodontal disease, the autologous mixed-lymphocyte reaction (AMLR), which is suggested as a possible indicator of immunoregulation in inflammatory diseases, of peripheral blood lymphocytes has been demonstrated to be depressed in some types/groups of the patients (low-AMLR patients), and a lower percentage of CD45RA positive cells in CD4-positive cells (CD4^+CD45RA^+ T cells) were observed in the low-AMLR patients. In the present study, the phenotypic alterations of the CD45 antigens (CD45RA and CD45RO) on CD4^+ T cells in the inflamed gingiva and peripheral blood lymphocytes from the patients with adult periodontitis were examined in relation to AMLR responses. The flowcytometric analysis of the T cell fraction in the inflamed gingiva revealed a relatively lower percentage of CD4^+CD45RA^+CD45RO^- T cells and a higher percentage of CD4^+CD45RA^-CD45RO^+ T cells than those in the peripheral blood, suggesting that naive CD4^+ T cells in the inflamed gingiva are actively differentiating into memory cell populations by the continuous stimulation of the local periodontopathic antigens. However, no significant correlation was observed between the alteration of these T cell subsets in the inflamed gingiva and AMLR responses nor the phenotypic alteration in the CD4^+ T cell subset of the peripheral blood lymphocytes from the individual subject. The CD4^+ CD45RA^-CD45RO^- and CD4^+CD45RA^+CD45RO^+ T cell subsets were also found in the inflamed gingiva from the periodontitis patients, although the functional characteristics of these T cell subsets has not been reported. These findings might reflect changes in the regulatory T cell function induced by development of periodontal diseases.

• 福岡歯科大学学会の論文
• 1995-06-30

著者

• 宗岡 孝志

  福岡歯科大学大学院歯学研究科保存学ii専攻

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• 歯周炎病巣局所におけるCD4^+CD45RA^+T細胞サブポピュレーションの動態
• 歯周炎病巣局所におけるCD4^+CD45RA^+T細胞サブポピュレーションの動態

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